Compare and book 5 Star hotels in Florida Keys, United States of America

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Check availability on Florida Keys 5 Star Hotels

Tonight
19 Apr - 20 Apr
Tomorrow
20 Apr - 21 Apr
Next weekend
25 Apr - 27 Apr
In two weeks
2 May - 4 May

Top Florida Keys 5 Star Hotels

Cheeca Lodge & Spa
Private beach, sun-loungers, beach umbrellas, beach towels

Cheeca Lodge & Spa

5.0 star property
9.0 out of 10, Wonderful, (1066)
"Beautiful property all around! Plenty of activities on property. Great food at the on property Atlantic's Edge Restaurant. Beautiful 'beach' but it's not especially sandy at all. Poor daily room refresh, may or may not complete the process. Leaky above counter sink, bugs in room (both dead and alive), glasses left on walkway outside our 3 floor room (a few got broken and broken glass left all over), vacuum cleaner left in elevator daily. Pizza box left for days on outside trash can by the...
The price is 6.201.499 ₫
8.726.691 ₫ total
includes taxes & fees
11 May - 12 May
Cheeca Lodge & Spa
Isla Bella Beach Resort & Spa
Property grounds

Isla Bella Beach Resort & Spa

5.0 star property
9.0 out of 10, Wonderful, (1010)
"Was an amazing experience "
The price is 6.152.240 ₫
8.470.608 ₫ total
includes taxes & fees
27 Apr - 28 Apr
Isla Bella Beach Resort & Spa
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Florida Keys.
Hawks Cay Resort

Hawks Cay Resort

61 Hawks Cay Blvd, Marathon, FL
The price is 6.368.722 ₫ per night from 27 Apr to 28 Apr
6.368.722 ₫
9.124.040 ₫ total
includes taxes & fees
27 Apr - 28 Apr
7.8/10 Good! (1,002 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Florida Keys

Jogging trails, fishing spots and popular sights from Everglades National Park to Duval Street—explore Florida Keys, a seaside destination also known for its live music scene.

See all hotels in Florida Keys
Higgs Beach showing tropical scenes and a beach as well as a large group of people

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Florida Keys?
How much you pay for a 5-star hotel in Florida Keys depends on factors like when you plan to go and the length of your stay. A top tip for bagging an awesome deal? Use our pricing filters to check out the available accommodation for your chosen dates.

  • Search for the lowest price per night from 5.619.461 ₫

What makes a hotel 5 stars in Florida Keys?
Impeccable guest service is integral to every 5-star hotel in Florida Keys. From the second you arrive, staff ensure your every need is met, whether recommending activities or providing a turn-down service. What’s more, hotels must feature superior conveniences to meet the standard for a 5-star rating. These can include luxury bathrooms, on-site spa facilities, swimming pools, gastronomic restaurants and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Florida Keys?
Find a luxurious retreat that includes your room, meals, drinks and entertainment in Florida Keys with the help of our filters. Search for hotels with a 5-star rating and select the “All inclusive” filter. Have a look at what’s included in the price. This way, you can take full advantage of all the perks on offer from the moment you arrive.
Are there any 5-star holiday rentals in Florida Keys?
Although there aren’t any 5-star holiday rentals in Florida Keys on our site, we have a range of properties that promise a terrific getaway. Find one that matches your needs by checking out our holiday rentals in Florida Keys.